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Seminar

Iqbal Hamza — Biochemistry / Redox Biology Center Seminar

“Heme Trafficking from the Ground-Up: Lessons from C. elegans”

Date:
Time:
4:00 pm – 5:00 pm
Beadle Center Room: N172
1901 Vine St
Lincoln NE 68503
Additional Info: BEAD
Contact:
Hannah Kahler, (402) 472-3173, redox2@unl.edu
Iqbal Hamza, Associate Professor, Department of Animal and Avian Sciences, University of Maryland, will present a seminar “Heme Trafficking from the Ground-Up: Lessons from C. elegans”.

Heme is a vital but cytotoxic cofactor responsible for diverse biological functions. Free heme is a hydrophobic and cytotoxic macrocycle. How then is heme transported through cellular membranes and organelles? Hamza pioneered the use of C. elegans to discover heme trafficking pathways because this roundworm is exceptional as it does not synthesize heme but rather utilizes environmental heme to manufacture heme-containing proteins which have human homologs. This research has uncovered several new molecules that traffic and regulate systemic heme homeostasis using genetic screens in C. elegans. Hamza’s findings represent major discoveries in heme trafficking and establish a paradigm for heme transport in animals.

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This event originated in Biochemistry.