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DTSTART;TZID=US/Central:20120927T153000
UID:70081@events.unl.edu
DTSTAMP:20020131T020000
SUMMARY:SBS Seminar - Donald Burke
DESCRIPTION:RNA world theories figure prominently in many scenarios for th
 e origin and early evolution of life, with RNA molecules acting both as t
 he dominant biocatalysts and as the repository of genetic information. In
  vitro selection has identified ribozymes that catalyze all of the major 
 reactions of genetic information transfer and many of the chemistries ass
 ociated with small molecule metabolism. A long-term goal of our program i
 s to build new biologies by building, understanding and exploiting metabo
 lic ribozymes. Early work examined metabolite binding by aptamers and str
 ucture-mechanism relationships in hammerhead ribozymes. Our recent focus 
 is on the evolution and engineering of ribozymes that catalyze phosphoryl
  transfer (kinase and phosphatase ribozymes) for biologically relevant su
 bstrates. We are especially interested in understanding how biophysical c
 onstraints dictate the evolutionary potential of RNA.\n\n
LOCATION:HAMILTON HALL Room 112
URL:http://events.unl.edu/2012/09/27/70081/
DTEND;TZID=US/Central:20120927T163000
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