Kennth Tew, Chairman, Department of Pharmacology, John C. West Chair in Cancer Research, Medical University of South Carolina, will present the seminar "Drug Biomarker Development on a Redox Platform" on Tues. January 22, 2013 at 4:00 PM in N172 Beadle Center.
Dr.Tew’s research employs an essential platform that interrogates redox pathways (with special emphasis on glutathione homeostasis) in drug discovery/development, drug resistance and biomarker identification in cancer. In oncology, there is a critical need to identify new drugs with clinical utility and biomarkers that correlate with drug responses. Recently, research has focused upon specific post-translationally modified, S-glutathionylated proteins that influence cell-signaling pathways and may serve as surrogate plasma biomarkers for oxidative and nitrosative stress. Translational research efforts have resulted in one glutathione S-transferase activated prodrug and two small molecule drugs that are under clinical development.