Dr. Steven Claypool, Assistant Professor, Department of Physiology, The Johns Hopkins University will present the seminar, "The Mitochondrion: A membrane-building power house" on Tues., Dec. 3, 2013 at 4:00 PM in N172 Beadle Center.
The mitochondrion’s role in phospholipid metabolism is vastly under-appreciated. The research in the Claypool lab is broadly interested in defining how lipids and membrane proteins interact to establish and maintain normal mitochondrial function and how derangements in this complex relationship result in pathophysiology. A major effort in the lab is to determine how a single lipid, cardiolipin, dictates the assembly and function of an obligate component of the oxidative phosphorylation machinery. Additional projects are focused on obtaining a more comprehensive molecular understanding of the basic cell biology of the metabolism of two lipids made in mitochondria, cardiolipin and phosphatidylethanolamine, the trafficking steps required for their production and distribution, and how these pathways are regulated.