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Seminar

Armen Petrosyan — CBC/RBC Seminar

Date:
Time:
4:00 pm – 5:00 pm
Beadle Center Room: Room N172
1901 Vine St
Lincoln NE 68503
Additional Info: BEAD
Contact:
Carol Hegel, (402) 472-2932, carol.hegel@unl.edu
“Tug of war in the Golgi: fight between compact and fragmented phenotypes” will be presented by Armen Petrosyan, MD, PhD, assistant professor, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center.

The abnormal glycosylation is one of the most interesting “signatures” of cancer. The identification of aberrant cancer-specific glycan structures of immunoglobulin G was the target of my PhD dissertation. But an understanding of the mechanisms of this alteration came later, when I observed the connection between the Golgi fragmentation and function of Golgi residential and matrix proteins. Recently, our group revealed the mechanism of Golgi disorganization in advanced prostate cancer and found that loss of the intercisternal connection in the Golgi is required for cancer cells to obtain aggressive phenotype and avoid apoptosis. Currently, I am working on the Golgi alteration in ethanol-treated hepatocytes, which may elucidate how alcohol treatment-induced Golgi fragmentation results in elevated apoptosis of hepatocytes.

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