Biological nanotechnology promises to create custom nanomachines to revolutionize the engineering of materials, catalysts, biomedical diagnostics, and therapeutics. Recent years have seen rapid progress in RNA nanotechnology, inspired by natural RNA machines that can sense molecules, carry out complex computations, and recruit proteins and other molecules. Despite RNA’s design potential, its full promise has yet to be realized. Dr. Joseph Yesselman will present a new automated design toolkit, RNAMake, which resolves the difficulties that have plagued RNA nanostructure design.