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SVMBS Research Seminar Series – Liu (Leah) Wang

Identification of Filovirus Entry Inhibitors Targeting the Endosomal Receptor NPC1 Binding Site

Date: Time: 4:00 pm
SVMBS Zoom Webinar
Contact: Marcia M Oetjen,
Please join us for a Zoom seminar presented by Liu (Leah) Wang, graduate student in the UNL School of Veterinary Medicine and Biomedical Sciences.

Filoviruses, mainly consisting of Ebola viruses (EBOV) and Marburg viruses (MARV), are enveloped negative-strand RNA viruses which can infect humans to cause severe hemorrhagic fevers and outbreaks with high mortality rates. The filovirus infection is mediated by the interaction of viral envelope glycoprotein (GP) and the human endosomal receptor Niemann-Pick C1 (NPC1). Blocking this interaction will prevent the infection. In conclusion, this work has identified several qualified lead-compounds for further drug development against filovirus infection.

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