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Dr. Thomas Tomasiak, University of Arizona - CBC/RBC Seminar

Allosteric regulation of drug/metabolite transporters by intrinsically disordered domains and substrate

Date: Time: 4:00 pm–5:00 pm
Beadle Center Room: E103
Additional Info: BEAD
Contact: Diana Bonham, (402) 472-2932, dbonham2@unl.edu
Transporters are the gatekeepers of the cell that serve vital homeostatic and protective roles for the membrane. We use cryo-EM and biophysical approaches to understand how they are regulated, which often involves difficult to trap intermediates of disordered or flexible domains. Our structure of BmrCD, a bacterial drug transporter, traps never before seen ternary complex bound with substrate and ATP. Another related structure of Yeast Cadmium Factor 1, a fungal metabolite transporter, reveals how a disordered domain is ordered upon phosphorylation to impact the central transporter architecture.

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This event originated in Biochemistry.