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CBC/RBC seminar - Dr. Michaela Gack, Cleveland Clinic

Novel Mechanisms of Virus Sensing in Innate Immunity

4:00 pm – 5:00 pm
Via Zoom presentation
Meeting ID: 923 4541 3700 Passcode: 778480
Diana Bonham, (402) 472-2932,
The RIG-I-like receptor (RLR) family of cytosolic RNA sensors is crucial for eliciting innate immune defenses against a variety of viruses including influenza, SARS-CoV-2 and Zika virus. Emerging evidence suggests that RLRs also play a major role in sensing certain DNA viruses. In this seminar, I will present our research work defining the mechanisms by which RLRs are activated upon virus infection to initiate type I interferon responses. I will also present our recent work on characterizing the tactical strategies employed by viruses to escape RLR-mediated innate immunity.

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This event originated in Biochemistry.