The Department of Energy’s National Laboratories are an outgrowth of investment in scientific research by the U.S. Government during World War II, and today tackle large-scale complex research problems in the interest of the nation. I discuss the origins of mathematics and computing and the labs, followed by current capabilities, initiatives, and research efforts in these areas at the Oak Ridge National Laboratory (ORNL), with an eye towards the future. I conclude with opportunities for engagement with ORNL and the national laboratories.