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BME Seminar Series: Development and Use of Carbon Nanotube Sensors for Quantification of Reactive Species

Presenter: Dr. Nicole Iverson

Date: Time: 12:00 pm
Scott Engineering Center Room: 111
Additional Info: SEC
Fluorescent sensors are frequently not used for in vivo research due to photobleaching and difficulty in signal detection. Single walled carbon nanotubes (SWNT) circumvent these issues with near infrared fluorescent emission and long-term stability; yet detection of carbon nanotube sensors has never before been performed in large animal models. The ability to place and read SWNT sensors in vivo for a large animal requires specialized instrumentation and research facilities. By teaming up with large animal veterinarians and meat scientists, our lab was able to surgically place, monitor, and recover SWNT sensors from 14 sheep. We examined various SWNT platforms, implantation locations, and detection methods to determine a strategy for frequent, consistent detection of SWNT sensors that serve as an indicator of animal stress and overall health.

About the presenter: Dr. Nicole Iverson received her doctorate degree from the Department of Biomedical Engineering at Rutgers University. She then went to the Massachusetts Institute of Technology (MIT) for her post doctorate research under the direction of a toxicologist, chemist, and chemical engineer – providing a well-rounded vision of the research possibilities. Dr. Iverson started working with carbon nanotubes while at MIT, becoming the first person to place carbon nanotube sensors into a live animal.

Iverson expanded her research into the biomedical engineering arena by focusing on the use of intracellular and extracellular carbon nanotube sensors. In the past seven years the Iverson Lab has developed an extracellular nitric oxide detection platform, real time in vivo sensors, and the first model that relates carbon nanotube sensor fluorescence to nitric oxide concentrations. The Iverson Lab is the only group that has been able to demonstrate carbon nanotube sensor detection within a large animal model. Researchers in the lab are currently expanding knowledge on the different levels of nitric oxide associated with cancer progression, developing novel sensor delivery platforms, and creating the first ever ratiometric carbon nanotube sensor for quantification of hydrogen peroxide both with and without the presence of other reactive species. Dr. Iverson has been the co-inventor on three patents and is the author on over 25 papers, with an h-index of 19.

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