Cells have evolved exquisite mechanisms to coordinate cellular survival/death, proliferation, differentiation, and repair with metabolic states. It is, therefore, not surprising that proteins with canonical roles in cell death/survival also modulate nutrient and energy metabolism and vice versa. The finding that many BCL-2 proteins reside at mitochondria or can translocate to this organelle has long motivated investigation into their involvement in normal mitochondrial physiology and metabolism. This has led to the discovery of homeostatic roles for BCL-2 proteins beyond regulation of apoptosis. In this seminar, I will discuss findings that link select BCL-2 proteins to cellular fuel utilization patterns and their relevance in metabolic physiology.