Research in the Bothner lab has two main focuses: (1) Investigation of cellular response to stress using chemical biology, proteomics, and metabolomics; and (2) Assembly, stability, and dynamics of multi-subunit enzymes and nucleoprotein complexes. Our research takes us from the atomic scale provided by high resolution structural models of viruses and enzymes to the complex interaction networks of nucleic acids, metabolites, and proteins that make up a living system.