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Seminar

David P. Giedroc – CBC/RBC Seminar

Date:
Time:
4:00 pm – 5:00 pm
Beadle Center Room: N172
1901 Vine St
Lincoln NE 68503
Additional Info: BEAD
Contact:
Carol Hegel, (402) 472-2932, carol.hegel@unl.edu
“Fighting over metals: Transition metal homeostasis at the host-microbial pathogen interface” presented by Dr. David P. Giedroc, chemistry alumni professor, Department of Chemistry, Indiana University.

We currently work on three separate projects under a common umbrella we term the biophysical chemistry of infectious disease. How cells regulate the intracellular availability of late d-block first row transition metals, from Mn to Zn, so as to avoid off-target toxicity, is a subject of long-standing interest in my laboratory. We have extensive experience using NMR, crystallographic, bioinorganic and biophysical methods to elucidate physical pathways of allosteric linkage in metalloregulatory or “metal sensor” proteins from bacterial pathogens, and how such linkages are dependent on the binding of a specific transition metal ion. This process controls metal homeostasis and resistance, which plays an important role at the host-bacterial pathogen interface. Other projects are focused on understanding the role of reactive sulfur species (RSS) in microbial pathogen resistance against antibiotics and host-imposed reactive nitrogen species stress, and molecular mechanisms of coronavirus (CoV) replication, including the causative agents of SARS and MERS.

www.biochem.unl.edu

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This event originated in Biochemistry.