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BSE Colloquium Series – Shannon Servoss, Ph.D.

Peptoid Microspheres: Characterization and Applications

Date: Time: 12:00 pm
Chase Hall Room: 219
Additional Info: CHA
Contact: Rebecca Wachs, (402) 472-2262,
Dr. Shannon Servoss is an associate professor of chemical engineering at the University of Arkansas. Her research group focuses on the design and characterization of peptoids for biomedical applications.
Peptoids are protease-resistant oligomers that harness similarities to peptides for biomimetic functionality. They have potential for use in biomedical applications, including disease detection and biosensors, due to their high bioavailability and low immunogenicity. The incorporation of chiral, aromatic side chains in the peptoid sequence allows for the formation of distinct secondary structures and self-assembly into supramolecular assemblies, including microspheres. Peptoid microspheres can be coated onto substrates for use in biosensor technologies, tissue engineering platforms, and drug-delivery systems. In order to be useful for these applications, the peptoid coatings must be robust under physiological conditions. Work in our lab shows that microsphere size decreases with increasing peptoid helicity and the positively charged side chains are positioned on the outside of the microspheres. The peptoid microsphere coatings are robust under physiological conditions, but degrade in acidic conditions (pH < 7) and at low ionic strengths (< 150 µM). Our lab has tested the performance of the peptoid microsphere coatings for ELISA microarray and tissue engineering. The increased surface area provided by the peptoid microspheres leads to increased dynamic range for ELISA microarray experiments. The coatings have been shown to be non-toxic to various cells and facilitate the differentiation of neuronal stem cells to neurons.

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This event originated in Biological Systems Engineering.