With recent breakthroughs in AI like Chat-GPT and DALL-E 2 making headlines, it’s natural to ask what role machine learning will play in fields such as science, technology, business, and education. In this talk I will outline three broad modes through which machine learning can be applied to the field of pure mathematics. The main examples I will use come from the fields of knot theory and low-dimensional topology, though I will also include examples from other fields of pure mathematics where applicable. These applications will range from approaches that have already been successfully implemented to more speculative works-in-progress.