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Food for Health Seminar Series – Matthew T. Andrews

12:00 pm – 1:00 pm
Food Innovation Center (FIC) & Zoom Room: 277
1901 N 21st St
Lincoln NE 68508
Allie Eaton, (402) 472-1862,
Matthew T. Andrews, PhD will present as part of the Food for Health Seminar Series. Dr. Andrews is the Director of NSF EPSCoR for the state of Nebraska and Professor in the School of Natural Resources at UNL. Website:

Talk Title: “Contributions of mammalian hibernation to human medicine”

Talk Abstract:
Mammals that hibernate can slow their metabolism, which in turn reduces their body temperature and leads to a state of suspended animation characterized by hypothermic torpor. For this metabolic rate reduction to occur on a whole-body scale, molecular adaptations that change the physiology of cells, tissues and organs are required, resulting in a major departure from normal mammalian homeostasis. Over the past decade, the research community has begun to develop a better understanding of the molecular interactions that serve as the mechanistic basis of hibernation in mammals. With this knowledge comes the potential for applying hibernation strategies for the improvement of human health. Minimizing disuse atrophy in muscles and bones, extending the time of organ preservation, improving treatment of trauma and hemorrhagic shock, developing new strategies to combat obesity and preventing debilitating reperfusion injury following myocardial infarction and stroke are some examples of situations where hibernation strategies can contribute to human medicine. One medical application of hibernation includes development of a small-volume (1 ml/kg) fluid to avoid damage associated with ischemia and reperfusion injury that can occur during hemorrhagic shock and organ preservation. This fluid is composed of the D-stereoisomer of ?-hydroxybutyrate (D-BHB) and melatonin. During hibernation D-BHB is a circulating 4-carbon fuel source that crosses the blood brain barrier and is catabolized in the heart and brain without generating lactic acid. Melatonin is a potent antioxidant that naturally peaks in the blood throughout hibernation during periodic arousals from torpor and decreases shock-induced oxidative stress through its inherent antioxidant action and receptor-mediated effects.

An in-person reception will be hosted at 11:30am, outside FIC 277 auditorium on Innovation Campus.
Seminar: Noon - 1pm CT
This seminar will be in-person & streamed via Zoom.

Email Allie Eaton for Zoom connection information.

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This event originated in Nebraska Food for Health Center.