Colloquium
Time:
Canceled: Colloquium: Dr. Ramez Daniel
Date:
3:30 pm –
4:30 pm
Virtual Location:
Zoom
Target Audiences:
“Synthetic Biology — Where Computer Logic Meets Cell Biology”
Dr. Ramez Daniel
Associate Professor
The Laboratory of Synthetic Biology and Bioelectronics (LSB2), Israel Institute of Technology, Haifa, Israel
Zoom Meeting: https://unl.zoom.us/j/95004324678
Meeting ID: 950 0432 4678
The design of biological computers interacting with bio-compounds for cellular control, processing, storage, and actuation using gene circuits inside living cells is gaining prominence due to their capabilities for solving significant challenges in biotechnological and medical applications. For example, synthetic gene circuits for cancer therapy are required to perform sophisticated tasks such as targeting malignant cells, avoiding damage to healthy cells and overmedication, and adapting to cell heterogeneity and environmental changes. Such systems often include sensory systems that receive gradual signals combined with decision-making capability for drug release. In this seminar, I will review the current state of gene circuits, with some of its applications and its technical challenges. Then, I will show our recent study, which describes the design principles of genetically encoded analog-to-digital converters (ADC) in living cells. The ADC circuit can be easily reconfigured to other functions and is useful for various intracellular and extracellular biosensing applications as a ternary switch with distinct low, medium, and high output states. Finally, I will describe a new computing approach that allows the implementation of artificial neural networks in living cells.
Prof. Ramez Daniel is an Associate Professor leading the Synthetic Biology and Bioelectronics group in the department of biomedical engineering at Technion - Israel Institute of Technology. Ramez received the B.Sc. degree in electrical engineering from Israel Institute of Technology in 2001, and the M.Sc. and Ph.D. in electrical engineering from Tel-Aviv University in 2010. From 2000 to 2006 Ramez was with Tower Semiconductor as a device/design engineer, and was a post-doctoral research fellow at Massachusetts Institute of Technology (MIT) from 2010-2014. During his work in MIT, Ramez has pioneered a new approach to design biological circuits called “analog genetic circuits”. Ramez won several awards and prizes (Leader in Science and Technology young academic chair, MAOF Fellowship for new faculty members, VATAT Fellowship for Ph.D. Study, Cum Laude for M.Sc. Study). His current research is focused on synthetic computation in living cells, bioelectronics and bioinspired technology for biomedical and biotechnology applications.
Dr. Ramez Daniel
Associate Professor
The Laboratory of Synthetic Biology and Bioelectronics (LSB2), Israel Institute of Technology, Haifa, Israel
Zoom Meeting: https://unl.zoom.us/j/95004324678
Meeting ID: 950 0432 4678
The design of biological computers interacting with bio-compounds for cellular control, processing, storage, and actuation using gene circuits inside living cells is gaining prominence due to their capabilities for solving significant challenges in biotechnological and medical applications. For example, synthetic gene circuits for cancer therapy are required to perform sophisticated tasks such as targeting malignant cells, avoiding damage to healthy cells and overmedication, and adapting to cell heterogeneity and environmental changes. Such systems often include sensory systems that receive gradual signals combined with decision-making capability for drug release. In this seminar, I will review the current state of gene circuits, with some of its applications and its technical challenges. Then, I will show our recent study, which describes the design principles of genetically encoded analog-to-digital converters (ADC) in living cells. The ADC circuit can be easily reconfigured to other functions and is useful for various intracellular and extracellular biosensing applications as a ternary switch with distinct low, medium, and high output states. Finally, I will describe a new computing approach that allows the implementation of artificial neural networks in living cells.
Prof. Ramez Daniel is an Associate Professor leading the Synthetic Biology and Bioelectronics group in the department of biomedical engineering at Technion - Israel Institute of Technology. Ramez received the B.Sc. degree in electrical engineering from Israel Institute of Technology in 2001, and the M.Sc. and Ph.D. in electrical engineering from Tel-Aviv University in 2010. From 2000 to 2006 Ramez was with Tower Semiconductor as a device/design engineer, and was a post-doctoral research fellow at Massachusetts Institute of Technology (MIT) from 2010-2014. During his work in MIT, Ramez has pioneered a new approach to design biological circuits called “analog genetic circuits”. Ramez won several awards and prizes (Leader in Science and Technology young academic chair, MAOF Fellowship for new faculty members, VATAT Fellowship for Ph.D. Study, Cum Laude for M.Sc. Study). His current research is focused on synthetic computation in living cells, bioelectronics and bioinspired technology for biomedical and biotechnology applications.