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NPOD Seminar - Huabo Su (Online via Zoom)

Neddylation, a small protein modification with a huge impact on the heart

12:00 pm–1:00 pm
via Zoom
Verona Skomski,
Dr. Huabo Su is an Associate Professor in the Department of Pharmacology and Toxicology at Augusta University, Georgia.
Post-translational modifications (PTMs) by a family of small protein modifiers, including ubiquitin (Ub) and Ub-like proteins, represent a vital mechanism regulating protein function and are integral to cellular homeostasis. Recent studies have consistently proven the fundamental importance of these PTMs in normal cell function and their implications in a wide array of diseases ranging from cancers, viral diseases, to neurodegenerative disorders and cardiovascular diseases. However, the biological functions of novel ubiquitin-like proteins in the heart remain poorly understood.
Dr. Su is particularly interested in the roles of NEDD8 (Neural precursor cell expressed, developmentally downregulated 8) and Ufm1 (Ubiquitin-like protein modifier 1), two novel Ub-like proteins, in the heart. NEDD8 and Ufm1 modify protein targets via their specific conjugation enzymes, termed neddylation and ufmylation, respectively. His research aims to address three major questions: 1) does neddylation or ufmylation have any roles in the developing and stressed hearts? 2) how does neddylation or ufmylation control cardiomyocyte function and survial? and 3) what cellular proteins are modified by NEDD8 or Ufm1 and how such modifications alter their molecular, cellular, organismal functions? They use a combination of novel genetically engineered mouse models with advanced molecular, cellular, physiological and pathological, and proteomic descriptors to tackle these questions.
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Meeting ID: 921 2980 9693
Passcode: 161700

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